Valencene

Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model[1][2][3].

Product Specifications

CAS Number

[4630-07-3]

UNSPSC

12352211

Hazard Statement

H304

Target

Interleukin Related; NF-κB

Type

Natural Products

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/valencene.html

Concentration

10mM

Purity

81.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C=C([C@@H]1CCC2=CCC[C@@H](C)[C@]2(C)C1)C

Molecular Formula

C15H24

Molecular Weight

204.35

Precautions

H304

References & Citations

[1]Yang IJ, et al. Inhibitory Effect of Valencene on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. Evid Based Complement Alternat Med. 2016;2016:9370893.|[2]Frohwitter J, et al. Production of the sesquiterpene (+) -valencene by metabolically engineered Corynebacterium glutamicum. J Biotechnol. 2014 Dec 10;191:205-13.|[3]Marques FM, et al. In vitro anti-inflammatory activity of terpenes via suppression of superoxide and nitric oxide generation and the NF-κB signalling pathway. Inflammopharmacology. 2019 Apr;27 (2) :281-289.