2-Acetamidofluorene

2-Acetamidofluorene is a potent carcinogenan. 2-Acetamidofluorene is can be used fot induction of hepatocellular carcinoma (HCC) and multiple primary tumours[1][2].

Product Specifications

CAS Number

[53-96-3]

UNSPSC

12352005

Hazard Statement

H302, H350

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-acetamidofluorene.html

Concentration

10mM

Purity

99.50

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(NC1=CC2=C(C=C1)C(C=CC=C3)=C3C2)=O

Molecular Formula

C15H13NO

Molecular Weight

223.28

Precautions

H302, H350

References & Citations

[1]Tan B, et al. Anti-hepatoma effect of arsenic trioxide on experimental liver cancer induced by 2-acetamidofluorene in rats. World J Gastroenterol. 2005 Oct 14;11 (38) :5938-43.|[2]CAMPBELL JG. Induction of multiple primary tumours in fowls with 2-acetamidofluorene. Br J Cancer. 1955 Mar;9 (1) :163-9.|[3]Y S Ho, et al. N-nitroso-2-acetylaminofluorene: a direct-acting carcinogen inducing hepatocellular carcinoma in Sprague-Dawley rats. Jpn J Cancer Res. 1994 Aug;85 (8) :794-800.