TP0438836

TP0438836 (compound 30b) is a SGLT1 inhibitor, with IC50 values of 28 nM and 7 nM for hSGLT1 and hSGLT2, respectively. TP0438836 can be used in diabetes research[1].

Product Specifications

CAS Number

[957772-01-9]

UNSPSC

12352005

Target

SGLT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tp0438836.html

Smiles

O[C@H]1[C@H](C2=CC(CC3=CC=C(C=C3)CCNC(NC(CO)(CO)CO)=O)=C(C=C2O)C)O[C@@H]([C@H]([C@@H]1O)O)CO

Molecular Formula

C27H38N2O10

Molecular Weight

550.60

References & Citations

[1]Kuroda S, et al. Discovery of a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor (TP0438836) for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2018 Dec 1;28 (22) :3534-3539.