Hydroxytyrosol

Hydroxytyrosol (DOPET) is a phenol found in the olive oil. Hydroxytyrosol can alleviate oxidative stress and improve mitochondrial function, thereby exerting neuroprotective effects. Hydroxytyrosol can induce cancer cells apoptosis via inducing ROS production. Hydroxytyrosol shows antibacterial and antiviral effect. Hydroxytyrosol can be used for the researches of cancer, infection, inflammation, immunology, metabolic, neurological and cardiovascular disease, such as colon cancer, diabetes, Alzheimer's Disease and atherosclerosis[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[10597-60-1]

Product Name Alternative

DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Bacterial; Reactive Oxygen Species (ROS) ; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hydroxytyrosol.html

Purity

99.85

Solubility

DMSO : 125 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(CCO)C=C1O

Molecular Formula

C8H10O3

Molecular Weight

154.16

Precautions

H302

References & Citations

[1]Alblihed MA, et al. Hydroxytyrosol ameliorates oxidative challenge and inflammatory response associated with lipopolysaccharide-mediated sepsis in mice. Hum Exp Toxicol. 2021 Feb;40 (2) :342-354. |[2]Acín S, et al. Hydroxytyrosol administration enhances atherosclerotic lesion development in apo E deficient mice. J Biochem. 2006 Sep;140 (3) :383-91.|[3]Peng Y, et al. Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice. Mol Nutr Food Res. 2016 Nov;60 (11) :2331-2342.|[4]Marina Aparicio-Soto, et al. Dietary hydroxytyrosol and hydroxytyrosyl acetate supplementation prevent pristane-induced systemic lupus erythematous in mice, Journal of Functional Foods, Volume 29, 2017, Pages 84-92.|[5]Masih Ghalandari, et al. Antimicrobial effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Hydroxytyrosol Oleate on Staphylococcus Aureus and Staphylococcus Epidermidis. ELECTRON J GEN MED, Volume 15, Issue 4, August 2018, Article No: em46|[6]Reyes JJ, et al. Neuroprotective Effect of Hydroxytyrosol in Experimental Diabetes Mellitus. J Agric Food Chem. 2017 Jun 7;65 (22) :4378-4383.|[7]Sun L, et al. Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation. Food Funct. 2014 Aug;5 (8) :1909-14.|[8]Paolacci S, et al. In vitro and clinical studies on the efficacy of α-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection. Eur Rev Med Pharmacol Sci. 2021 Dec;25 (1 Suppl) :81-89.