Unesbulin

Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity[1][2].

Product Specifications

CAS Number

[1610964-64-1]

Product Name Alternative

PTC596

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; BMI1

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ptc596.html

Purity

99.17

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

NC1=C(F)C(NC2=CC=C(C(F)(F)F)C=C2)=NC(N3C4=CC(F)=CC=C4N=C3C)=N1

Molecular Formula

C19H13F5N6

Molecular Weight

420.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Nishida Y, et al. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer J. 2017 Feb 17;7 (2) :e527.|[2]BMI1 inhibitor PTC596