Pam3CSK4

Formula : C81H156N10O13S.3HCl MW: 1510.3 . 109.4 Selective agonist of TLR1/TLR2 complex. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Potent and effective immune adjuvant. Exerts strong local response, enhances IgG2a and IgG1 titers and upregulates proinflammatory and Th1 cytokine genes. Potent activator of the proinflammatory transcription factor NF-κB.

Product Specifications

Product Name Alternative

Pam3CSK4; Pam3Cys-SKKKK; (S) -[2,3-Bis (palmitoyloxy) - (2- RS) -propyl]-N-palmitoyl- (R) -Cys- (S) -Ser- (S) -Lys4-OH

Applications

Functional Assay

Components

(1mg/ml) in Sterile Water

Storage Conditions

Store the product at 4°C for short term and at -20°C for long-term storage. Product is stable for 2 years at -20°C.

Applications Notes

Purity: Absence of detectable protein or DNA contaminants with agonistic TLR activity. Solubility: Soluble in water, saline or aqueous buffers at pH <7.5.