Capecitabine

Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.

Product Specifications

CAS Number

[154361-50-9]

UNSPSC

12352005

Hazard Statement

H341, H350, H360, H402

Target

Apoptosis; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Capecitabine.html

Purity

99.99

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=C(C(NC(OCCCCC)=O)=NC2=O)F)O[C@@H]1C

Molecular Formula

C15H22FN3O6

Molecular Weight

359.35

Precautions

H341, H350, H360, H402

References & Citations

[1]PharmD CM, et al. Capecitabine: A review. Clinical Therapeutics. 2005 Jan; 27 (1) : 23-44.|[2]Guichard SM, et al. Gene expression predicts differential capecitabine metabolism, impacting on both pharmacokinetics and antitumour activity. Eur J Cancer. 2008 Jan;44 (2) :310-7.