CLEC4M Human

Source:Sf9, Baculovirus cells.Physical Appearance:Sterile filtered colorless solution.Biological ActivitynullC-type Lectin Domain Family 4, Member M (CLEC4M) is a type II integral membrane proteinand A pathogen-recognition receptor which takes part in peripheral immune surveillance in liver. CLEC4M mediates the endocytosis of pathogens which than degraded in lysosomal compartments. CLEC4M is a receptor for ICAM3, binding to mannose-like carbohydrates and also recognizes various evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses which among them are Ebola, hepatitis C, influenza A, HIV-1, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus.CLEC4M Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 570 amino acids (72-399 a.a) and having a molecular mass of 64.8kDa.CLEC4M is fused to a 239 amino acid hIgG-His-Tag at C-terminus & purified by proprietary chromatographic techniques.