C4 Human

Source:Human Plasma.Physical Appearance:Sterile filtered solution.Biological ActivitynullNative human C4 is aglycosylated polypeptide containing 3 disulfide-linked chains. C4 is essential to the activation of both thelectin and the classical pathways of complement activation.Initiation of each pathway generates proteolytic enzyme complexes which are bound to the target surface. These enzymes cleave a peptide bond in C4 releasing the anaphylatoxin C4a and activating C4b. Like C3, the thioester of metastable C4b is highly reactive and is capable of reacting and covalently coupling C4b to amino or hydroxyl groups on the target surface. C4A and C4B are 2 variants of C4 that are common in manwhereas, in animals who have only 1 type usually have C4B.Human Complement C4 produced in Human plasma having a molecular mass of 205 kDa.

Product Specifications

Product Name Alternative

Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A, CO4, CPAMD2.

Purification

Greater than 90.0% as determined by SDS-PAGE.

Format

C4 protein solution contains 10mM sodium phosphate and 145mM NaCl, pH 7.3.

Storage Conditions

C4 Human is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.