Pomalidomide-PEG4-C-COOH
Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
Product Specifications
CAS Number
[2097938-44-6]
Product Name Alternative
Cereblon Ligand -Linker Conjugates 1; E3 Ligase Ligand-Linker Conjugates 1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/14-__2-_2,6-dioxopiperidin-3-yl_-1,3-dioxoisoindolin-4-yl_amino_-3,6,9,12-tetraoxatetradecan-1-oic_acid.html
Purity
99.19
Solubility
DMSO : 50 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic)
Smiles
O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3NCCOCCOCCOCCOCC(O)=O
Molecular Formula
C23H29N3O10
Molecular Weight
507.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Guangrong Zheng, et al. Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof. WO2017184995A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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