MAPK11 Recombinant Protein

Source : Escherichia Coli. MAPK11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 387 amino acids (1-364 a.a.) and having a molecular mass of 43.8kDa.MAPK11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. MAPK11 belongs to the MAP kinase family and is most associated with p38 MAP kinases (MAPKs) . MAPKs are activated mainly as a reaction to cellular stress and inflammatory cytokines, and inhibitors that target the MAPK14 and MAPK11 have demonstrated ability to cure inflammatory disease. MAPK11 cooperates with HDAC3 and Promyelocytic leukemia protein and takes part in a signal transduction pathway which is activated by alterations in the osmolarity of the extracellular environment, by environmental stress, or by cytokines.