Anti-TLR4 Polyclonal Antibody

TLR4, Toll-like receptor 4, is a protein that in humans is encoded by the TLR4 gene. TLR 4 is a toll-like receptor. TLR4, the human homolog of Drosophila Toll, is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat region and an intracellular domain homologous to that of human interleukin-1 receptor. The TLR4 gene is mapped to chromosome 9q32-q33 by fluorescence in situ hybridization.It detects lipopolysaccharide from Gram-negative bacteria and is thus important in the activation of the innate immune system.The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.

Product Specifications

Product Name Alternative

Toll-like receptor 4; hToll; CD284; TLR4

Gene Name

TLR4

Gene ID

7099

UniProt

O00206

Host

Rabbit

Reactivity

Human

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human TLR4 (50-68aa DNLPFSTKNLDLSFNPLRH) .

Target Antigen

Toll-like receptor 4

Clonality

Polyclonal

Applications

Purification

Immunogen affinity purified.

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.