Polyclonal Antibody to TFE3
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5') . Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. Clark J., Lu Y.-J., Sidhar S.K., Parker C., Gill S. Oncogene 15:2233-2239 (1997) Weterman M.A.J., Wilbrink M., Proc. Natl. Acad. Sci. U.S.A. 93:15294-15298 (1996)
Product Specifications
Product Name Alternative
BHLHE33|| TFEA|| RCCP2
Gene Name
TFE3
Gene ID
7030
UniProt
P19532
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa.303~307 (L-D-V-Y-S) derived from Human TFE3.
Target Antigen
TFE3
Clonality
Polyclonal
Applications
WB
Format
Purified
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 70kd, Western blotting: 1:500~1:1000
Isotype
Rabbit IgG
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
