Smad3 (Phospho-Ser425) Antibody
Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. Modification: Phospho-Tyr1197
Product Specifications
Product Name Alternative
JV15-2; MAD-3; MADH3; Mad3; Mothers against DPP homolog 3
Gene Name
SMAD3
Gene ID
4088
UniProt
P84022
Host
Rabbit
Reactivity
Rat, Mouse, Human
Immunogen
Peptide sequence around phosphorylation site of serine 425 (C-S-S-V-S (p) ) derived from Human Smad3.
Target Antigen
Smad3
Clonality
Polyclonal
Applications
IHC, WB
Purification
Affinity-chromatography
Components
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Store at 4°C; For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Predicted MW: 52kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
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