Anti-Mouse LPAM-1 PE (Clone : DATK32)
Integrin alpha 4 / beta 7 (CD49d / Ly69), also known as LPAM-1 (Lymphocyte Peyer ́s patch adhesion molecule 1), is a heterodimeric (150 kDa / 130 kDa) integrin complex which mediates lymphocyte homing to Peyer ́s patch high endothelial venules and to the intestinal lamina propria. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. Ligands of LPAM-1 are MAdCAM-1, VCAM-1, and fibronectin, but the alpha 4 subunit (CD49d) can mediate also homotypic adhesion.Specificity : The rat monoclonal antibody DATK32 recognizes an extracellular epitope of integrin alpha 4 (CD49d) and integrin beta7 (Ly69) components of mouse LPAM-1 complex, which is expressed on the majority of peripheral lymphocytes, as well as on subsets of thymocytes and bone marrow cells.
Product Specifications
Product Name Alternative
Integrin alpha 4 beta 7, CD49d / Ly69
Gene Name
Itgb7
Gene ID
16421
Reactivity
Mouse
Immunogen
TK1 cells
Target Antigen
LPAM-1
Clonality
Monoclonal
Clone
DATK32
Applications
FACS
Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Components
0.5 mg/mLFormulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage Conditions
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.
Applications Notes
Flow cytometry: Recommended dilution: 2 μg/mL.
Isotype
Rat IgG2a kappa
Conjugate
PE
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