Polyclonal Antibody to POU3F2
POU3F2 is a developmental neural cell-specific POU domain transcription factor and is crucial for cell lineage determination. In melanoma lesions, cells expressing high levels of POU3F2 show enhanced invasive and metastatic capacity that can in part be explained by repression of MITF (Micropthalmia-associated Transcription Factor) expression via POU3F2 binding to its promoter. POU3F2 is expressed exclusively in the central nervous system, more specifically in post-mitotic neurons and glia.
Product Specifications
Product Name Alternative
POU3F2||BRN2||OCT7||OTF7
Gene Name
POU3F2
Gene ID
5454
UniProt
P20265
Host
Rabbit
Reactivity
Human
Immunogen
A partial length recombinant POU3F2 protein (amino acids 220-421) was used as the immunogen for this antibody.
Target Antigen
POU3F2
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2 μg/mL
Isotype
Rabbit IgG
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