Polyclonal Antibody to SpiB
Spi-B belongs to the ETS family transcription factor containing a conserved ETS domain which specifically binds to a purine-rich DNA sequence called the PU-box (5'-GAGGAA-3') . Spi-B has two known isoforms (28 and 18 kDa) and is localized in nucleus and cytoplasm. Spi-B contains two transactivation domains (TAD) at the N-terminal end which may be required for transcriptional activation of the target genes. Spi-B is involved in development of plasmacytoid dendritic cells (natural interferon producing cells) and B-cell development. Spi-B acts as a lymphoid specific enhancer. Spi-B is highly expressed in plasmacytoid dendritic cells (pDCs), B-cells and stem cell populations of the liver.
Product Specifications
Product Name Alternative
SPIB
Gene Name
SPIB
Gene ID
6689
UniProt
Q01892
Host
Rabbit
Reactivity
Human
Immunogen
Full length recombinant SpiB protein was used as the immunogen for this antibody.
Target Antigen
SpiB
Clonality
Polyclonal
Applications
WB
Purification
Protein A Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4μg/mL
Isotype
Rabbit IgG
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