Win 18446

Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes[1][2].

Product Specifications

CAS Number

[1477-57-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/win-18446.html

Purity

98.94

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl

Molecular Formula

C12H20Cl4N2O2

Molecular Weight

366.11

Precautions

H302, H315, H319, H335

References & Citations

[1]John K Amory, et al. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl. Jan-Feb 2011;32 (1) :111-9.|[2]Cathryn A Hogarth, et al. Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol Reprod. 2011 May;84 (5) :957-65.