Cabergoline

Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively) .

Product Specifications

CAS Number

[81409-90-7]

Product Name Alternative

FCE-21336

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Dopamine Receptor

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Cabergoline.html

Purity

99.86

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C=CCN1[C@@]2([H])[C@@](C[C@H](C1)C(N(CCCN(C)C)C(NCC)=O)=O)([H])C3=CC=CC4=C3C(C2)=CN4

Molecular Formula

C26H37N5O2

Molecular Weight

451.60

Precautions

H302, H315, H319, H335

References & Citations

[1]Odaka H, et al. Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9 (6) :e99271.|[2]Jefferson F, et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155 (11) :4411-21.