Astragaloside II

Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis[1][2][3][4][5].

Product Specifications

CAS Number

[84676-89-1]

Product Name Alternative

Astrasieversianin VIII

UNSPSC

12352005

Target

Autophagy; HIF/HIF Prolyl-Hydroxylase; Interleukin Related; NF-κB; SOD

Type

Natural Products

Related Pathways

Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Astragaloside-II.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H](O)[C@@H](OC(C)=O)[C@]([H])(O[C@@H]2C(C)(C)[C@@]([C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C[C@]4([H])[C@@]56CC[C@@]7(C)[C@@]4(C)C[C@H](O)[C@@]7([C@]8(C)O[C@H](C(O)(C)C)CC8)[H])([H])[C@]5(C6)CC2)OC1

Molecular Formula

C43H70O15

Molecular Weight

827.01

References & Citations

[1]Kong XH, et al. Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways. Int J Mol Med. 2012 Jun;29 (6) :1090-8.|[2]Huang C, et al. Reversal of P-glycoprotein-mediated multidrug resistance of human hepatic cancer cells by Astragaloside II. J Pharm Pharmacol. 2012 Dec;64 (12) :1741-50.|[3]Chun-ping Wan, et al. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity. Acta Pharmacol Sin. 2013 Apr;34 (4) :522-30.|[4]Wang M, et al. Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy. J Pharm Pharmacol. 2017 Jun;69 (6) :743-752.|[5]Qiao C, et al. Astragaloside II alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo. Am J Transl Res. 2019 Nov 15;11 (11) :7074-7083.