RO5166017

RO5166017 is an orally active and species-crosses TAAR1 agonist, with Ki values of 1.9 nM, 2.7 nM, 31 nM and 24 nM for mouse, rat, human and cynomolgus monkey, respectively[1].

Product Specifications

CAS Number

[1048346-74-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Trace Amine-associated Receptor (TAAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ro5166017.html

Purity

99.37

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CCN(C1=CC=CC=C1)C[C@@H]2N=C(N)OC2

Molecular Formula

C12H17N3O

Molecular Weight

219.29

Precautions

H302

References & Citations

[1]Florent G Revel, et al. TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A|[2]Justin N Siemian, et al. Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats. Behav Pharmacol. 2017 Oct;28 (7) :590-593.