Anti-GPM6A Antibody
Boster Bio Anti-GPM6A Antibody catalog # A06295. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Neuronal membrane glycoprotein M6-a; M6a; GPM6A; M6A
Gene Name
GPM6A
UniProt
P51674
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide of human GPM6A (NP_005268.1) .
Clonality
Polyclonal
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca (2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs) ; enhances internalization and recycling of mu-type opioid receptor.
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A06295
Product MSDS
https://www.bosterbio.com/msds?sku=A06295
Observed Molecular Weight
31210 MW
Gene Name Synonym
Neuronal membrane glycoprotein M6-a
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Cell projection, dendritic spine . Cell projection, filopodium . Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity) . .
Protein Name
Neuronal membrane glycoprotein M6-a
Contents
Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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