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Anti-Cyclin-dependent kinase 12 CDK12 Antibody

Boster Bio Anti-Cyclin-dependent kinase 12 CDK12 Antibody catalog # A03495. Tested in WB, ELISA applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Cyclin-dependent kinase 12;2.7.11.22;2.7.11.23; Cdc2-related kinase, arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12; CDK12; CRK7, CRKRS, KIAA0904

Gene Name

CDK12

UniProt

Q9NYV4

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Synthesized peptide derived from human protein at AA range: 50-130

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

WB, ELISA

Purification

CDK12 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A03495

Product MSDS

https://www.bosterbio.com/msds?sku=A03495

Observed Molecular Weight

164155 MW

Gene Name Synonym

Cyclin-dependent kinase 12

Subcellular Location

Nucleus. Nucleus speckle. Colocalized with nuclear speckles throughout interphase.

Protein Name

Cyclin-dependent kinase 12

Isotype

IgG

Contents

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.

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