Anti-Histone H4 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
Synonyms
H4C1; H4/A; H4FA; HIST1H4A; ; H4C2; H4/I; H4FI; HIST1H4B; ; H4C3; H4/G; H4FG; HIST1H4C; ; H4C4; H4/B; H4FB; HIST1H4D; ; H4C5; H4/J; H4FJ; HIST1H4E; ; H4C6; H4/C; H4FC; HIST1H4F; ; H4C8; H4/H; H4FH; HIST1H4H; ; H4C9; H4/M; H4FM; HIST1H4I; ; H4C11; H4/E; H4FE; HIST1H4J; ; H4C12; H4/D; H4FD; HIST1H4K; ; H4C13; H4/K; H4FK; HIST1H4L; ; H4C14; H4/N; H4F2; H4FN; HIST2H4; HIST2H4A; ; H4C15; H4/O; H4FO; HIST2H4B; ; H4-16; HIST4H4; Histone H4
Gene Name
H4C1/2/3/4/5/6/8/9/11/12/13/14/15/16
Gene ID
8370
UniProt
P62805
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human Histone H4 recombinant protein (Position: A16-R96) .
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Agalioti, T., Chen, G., Thanos, D. Deciphering the transcriptional histone acetylation code for a human gene. Cell 111: 381-392, 2002. 2. Albig, W., Kioschis, P., Poustka, A., Meergans, K., Doenecke, D. Human histone gene organization: nonregular arrangement within a large cluster. Genomics 40: 314-322, 1997. 3. Allen, B., Ostrer, H., Stein, J., Stein, G. Histone gene clusters map to chromosomes 1 and 6. (Abstract) Cytogenet. Cell Genet. 51: 950 only, 1989.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A14495-3-Fluoro488
Calculated Molecular Weight
11 kDa
Applications Notes
6
Gene Name Synonym
H4 clustered histone 14
Protein Name
Histone H4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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