CS-6253

CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimer’s disease[1][2][3].

Product Specifications

CAS Number

[1627911-44-7]

UNSPSC

12352209

Target

Amyloid-β; Apolipoprotein

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cs-6253.html

Purity

98.84

Solubility

DMSO : 2 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (adjust pH to 10 with NaOH)

Smiles

C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)C(C)C)=O)CCCNC(N)=O)=O)CO)=O)CCCCN)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCCCN)=O)CC(C)C)=O)CCCNC(=N)N)=O)C)=O)CC(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O)CCC(O)=O)=O)CCCNC(N)=O)=O)CC(C)C)=O)C)=O)C)=O)CC(C)C)=O)C=1C=2C(NC1)=CC=CC2

Molecular Formula

C136H228N36O43

Molecular Weight

3055.48

References & Citations

[1]Noveir SD, et al. Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys. Alzheimers Res Ther. 2022 Jun 24;14 (1) :87.|[2]Hafiane A, et al. ABCA1 Agonist Mimetic Peptide CS-6253 Induces Microparticles Release From Different Cell Types by ABCA1-Efflux-Dependent Mechanism. Can J Cardiol. 2019 Jun;35 (6) :770-781. |[3]Boehm-Cagan A, et al. ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies. J Alzheimers Dis. 2016 Oct 4;54 (3) :1219-1233.