LY-266500

LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei (IC50 =0.6 μM) and Leishmania donovani (IC50 =2.86 μM) . LY-266500 can be used for research on parasitic infections[1].

Product Specifications

CAS Number

[147104-27-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Mitochondrial Metabolism; Parasite

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C1C=CSN1C2=CC=C(C(Cl)=C2)F

Molecular Formula

C9H5ClFNOS

Molecular Weight

229.66

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hunger-Glaser I, et al. Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems. Mol Biochem Parasitol. 1999 May 15;100 (1) :53-9.