AMG-628
AMG-628 is an orally active inhibitor for TRPV1, that inhibits Capsaicin (HY-10448) or acid (pH 5) -induced Ca2+ influx into TRPV1- expressing CHO cell with IC50 of 4.9 and 3.1 nM. AMG-628 exhibits analgesic activity in Capsaicin (HY-10448) -induced rat model, and exhibits a half-life of 2.4 h in rats[1].
Product Specifications
CAS Number
[862269-93-0]
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC(NC1=NC2=C(OC3=NC=NC(N4CCN([C@@H](C5=CC=C(F)C=C5)C)CC4)=C3)C=CC=C2S1)=O
Molecular Formula
C25H25FN6O2S
Molecular Weight
492.57
References & Citations
[1]Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50 (15) :3528-39.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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