(E) -JP-2-196 (TFA)

JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders[1].

Product Specifications

CAS Number

[3065021-33-9]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Cancer

Purity

97.89

Smiles

OC(C(F)(F)F)=O.O=C(N1CCNCC1)/C=C/C(C2=CC=C(C=C2)OC)=O

Molecular Formula

C17H19F3N2O5

Molecular Weight

388.34

References & Citations

[1]Toriki, E. S., et al., (2023) . Rational Chemical Design of Molecular Glue Degraders. ACS central science, 9 (5), 915–926.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature, keep dry and cool

Scientific Category

Reference compound2

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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