ACI-3024

ACI-3024 is an an orally active and highly selective Tau protein aggregation inhibitor. ACI-3024 decrease the β-sheet content and seeding properties of pathological Tau from different Tauopathies, leading to a significant rescue of the Tau-induced neurodegeneration and neuroinflammation in a cellular model. ACI-3024 is promising for research of neurodegenerative diseases[1].

Product Specifications

CAS Number

[2361566-66-5]

UNSPSC

12352005

Target

Tau Protein

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

FC=1C=CC2=C(C1)NC3=C2CN(C=4C=CC=5OC(=NC5C4)N6CCOCC6)CC3

Molecular Formula

C22H21FN4O2

Molecular Weight

392.43

References & Citations

[1]Nisbet R M, et al. O5‐06‐04: CHARACTERIZATION OF NOVEL TAU‐SPECIFIC ANTIBODIES AND ENHANCEMENT OF THEIR DELIVERY INTO THE BRAIN USING FOCUSED SCANNING ULTRASOUND[J]. Alzheimer's & Dementia, 2019, 15: P1629-P1630.