MDI-403
MDI-403 is a retinoic acid receptor (RAR) agonist with an EC50 value of less than 1 μM. MDI-403 exhibits significant antiviral activity against SARS-CoV-2, and can dose-dependently inhibit the expression of viral nucleoprotein (NP) and reduce the proportion of infected cells. MDI-403 mainly acts during the virus invasion stage. MDI-403 can be used in research on anti-SARS-CoV-2[1].
Product Specifications
CAS Number
[127471-94-7]
UNSPSC
12352005
Target
RAR/RXR; SARS-CoV
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Infection
Smiles
C(=C/C(=C/C=C/C(=C\C(OCC(=O)C1=CC=C(OC)C=C1)=O)/C)/C)\C=2C(C)(C)CCCC2C
Molecular Formula
C29H36O4
Molecular Weight
448.59
References & Citations
[1]Riva L, et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature. 2020 Oct 1;586 (7827) :113-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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