TJU103
TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research[1].
Product Specifications
CAS Number
[10245-44-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Transmembrane Glycoprotein
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=NC=C1)N/N=C/C2=CNC3=C2C=CC=C3
Molecular Formula
C15H12N4O
Molecular Weight
264.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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