5-Fluorouridine 5'-phosphate

5-Fluorouridine 5'-phosphate is an ODCase (orotidine-5′-monophosphate decarboxylase) inhibitor, with a Ki value of 98 µM for human ODCase and a Ki value of 645 µM for Methanobacterium ODCase. 5-Fluorouridine 5'-phosphate exhibits inhibitory activity against leukemia and lymphoma cell lines and can be used in cancer research [1].

Product Specifications

CAS Number

[796-66-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.56

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N1)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=C(F)C1=O

Molecular Formula

C9H12FN2O9P

Molecular Weight

342.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Bello AM, et al. Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52 (6) :1648-58.