5-Fluorouridine 5'-phosphate
5-Fluorouridine 5'-phosphate is an ODCase (orotidine-5′-monophosphate decarboxylase) inhibitor, with a Ki value of 98 µM for human ODCase and a Ki value of 645 µM for Methanobacterium ODCase. 5-Fluorouridine 5'-phosphate exhibits inhibitory activity against leukemia and lymphoma cell lines and can be used in cancer research [1].
Product Specifications
CAS Number
[796-66-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.56
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N1)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=C(F)C1=O
Molecular Formula
C9H12FN2O9P
Molecular Weight
342.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Bello AM, et al. Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52 (6) :1648-58.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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