Adenosine-15N

Adenosine-15N (Adenine riboside-15N) is 15N labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

Product Specifications

CAS Number

[41547-82-4]

Product Name Alternative

Adenine riboside-15N; D-Adenosine-15N

UNSPSC

12352005

Target

Apoptosis; Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Smiles

O[C@H]1[C@H]([C@@H](O[C@@H]1CO)N2C3=C(N=C2)C([15NH2])=NC=N3)O

Molecular Formula

C10H13N4 15NO4

Molecular Weight

268.23

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98 (3) :1591-1625.|[3]Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14 (7) :1315-1323.|[4]Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41 (2) :829-838.|[5]Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111 (4) :904-915.