Flunisolide-d4

Flunisolide-d4 is the deuterium labeled Flunisolide (HY-B1121) . Flunisolide is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation[1][2].

Product Specifications

UNSPSC

12352211

Target

Apoptosis; Glucocorticoid Receptor; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Smiles

O=C1C=C[C@@]2(C([C@H](C[C@@]3([C@@]2([C@]([2H])(C[C@]4([C@@]3(C[C@@]5([C@]4(CCC5)C(C([2H])([2H])O)=O)[H])[H])C)O)[2H])[H])F)=C1)C

Molecular Formula

C24H27D4FO4

Molecular Weight

406.52

References & Citations

[1]Tatiana Paula Teixeira Ferreira, et al. Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. Front Endocrinol (Lausanne) . 2020 Jun 17;11:388. |[2]M Profita, et al. In vitro effects of flunisolide on MMP-9, TIMP-1, fibronectin, TGF-beta1 release and apoptosis in sputum cells freshly isolated from mild to moderate asthmatics. Allergy. 2004 Sep;59 (9) :927-32.