M-APTA

M-APTA (5'-S- (3-aminophenyl) -5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP) . m-APTA can be converted into adenine, which is a crucial step in protecting normal cells from the toxicity of nucleobase analogues (NBA) . m-APTA is promising for research of MTAP-deficient cancers[1].

Product Specifications

CAS Number

[86072-47-1]

Product Name Alternative

5′-S- (3-Aminophenyl) -5′-thioadenosine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphorylase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=CC=CC(SC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=NC(C3=NC=N4)=C4N)O2)=C1

Molecular Formula

C16H18N6O3S

Molecular Weight

374.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang S, et al. 5'-S- (3-aminophenyl) -5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers. Mol Cancer Ther. 2025 Mar 10.