Abemaciclib-d5

Abemaciclib-d5 (LY2835219-d5) is a deuterium labeled Abemaciclib (HY-16297A) [1][2][3].

Product Specifications

CAS Number

[1809251-51-1]

Product Name Alternative

LY2835219-d5

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Cancer

Smiles

CC(N1C(C)C)=NC(C1=CC(C2=C(C=NC(NC3=CC=C(CN4CCN(C([2H])(C([2H])([2H])[2H])[2H])CC4)C=N3)=N2)F)=C5)=C5F

Molecular Formula

C27H27D5F2N8

Molecular Weight

511.62

References & Citations

[1]Ku BM, et al. The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. Oncotarget. 2016 Mar 22;7 (12) :14803-13.|[2]Yadav V, et al. The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation. Mol Cancer Ther. 2014 Oct;13 (10) :2253-63.|[3]Gelbert LM, et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest New Drugs. 2014 Oct;32 (5) :825-37.