5α-Androstan-3α-ol
5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor) . 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms[1].
Product Specifications
CAS Number
[7657-50-3]
Product Name Alternative
3α,5α-Androstanol
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Constitutive Androstane Receptor; GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(CCC4)C
Molecular Formula
C19H32O
Molecular Weight
276.46
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kliewer SA, et al. Orphan nuclear receptors: shifting endocrinology into reverse. Science. 1999 Apr 30;284 (5415) :757-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
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