(S) -Thalidomide-4-OH
(S) -Thalidomide-4-OH is the S-isomer of Thalidomide-4-OH (HY-103596) . Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
CAS Number
[2357105-36-1]
UNSPSC
12352005
Hazard Statement
H302, H361
Target
Drug Isomer
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.0
Smiles
OC1=C2C(N(C(C2=CC=C1)=O)[C@H]3CCC(NC3=O)=O)=O
Molecular Formula
C13H10N2O5
Molecular Weight
274.23
Precautions
H302, H361
References & Citations
[1]Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25 (5) :597-604.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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