Thalidomide-5- (PEG2-amine)
Thalidomide-5- (PEG2-amine) is a PROTAC building block that contains an E3 ligase ligand substituted with a terminal amine group. The amine group can react with NHS ester group or carboxylic acid in the presence of EDC or HATU. The PEG spacer improves water solubility.
Product Specifications
CAS Number
[2550398-08-6]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NCCOCCOCCNC(C1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O)=O
Molecular Formula
C20H24N4O7
Molecular Weight
432.43
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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