Thujopsene

Thujopsene is the inhibitor for cytochrome P450, that inhibits CYP2B6, CYP3A4, CYP2C19, CYP2C8, CYP2C9 with IC50s of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. Thujopsene binds to PKM2, inhibits the metabolism pathway of cancer cell, induces apoptosis in MKN45, thereby exhibiting antitumor efficacy. Thujopsene exhibits anti-termite and antifungal activities through autoxidation[1][2][3].

Product Specifications

CAS Number

[470-40-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Cytochrome P450; Fungal; Insecticide; Pyruvate Kinase

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection

Purity

86.31

Smiles

CC1(C)[C@]23[C@](C3)([H])C(C)=CC[C@]2(C)CCC1

Molecular Formula

C15H24

Molecular Weight

204.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Jeong HU, et al., Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77 (22-24) :1522-32.|[2]Nagata T, et al. Evaporated fraction of thujopsene from Thujopsis dolabrata starves cancer cells via PKM2 Anti-tumor effect of the volatile components of Thujopsis dolabrata[J]. 2023.|[3]Mukai A, et al. Antitermite and antifungal activities of thujopsene natural autoxidation products[J]. European Journal of Wood and Wood Products, 2019, 77: 311-317.

Shipping Conditions

Room Temperature

Storage Conditions

Store at room temperature 3 years

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP2; CYP3

Available Sizes

Curated Selection

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