D-α-Methyl DOPA
D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. D-α-Methyl DOPA occupies a pocket along the DQ8 peptide binding groove. D-α-Methyl DOPA inhibits the binding of a DQ8 peptide to an MHC class II molecule for presentation to CD4+ T cells, thereby slowing the development or progression of type 1 diabete or celiac disease[1].
Product Specifications
CAS Number
[2799-15-7]
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
MHC
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Metabolic Disease
Smiles
OC1=CC(=CC=C1O)C[C@](N)(C)C(O)=O
Molecular Formula
C10H13NO4
Molecular Weight
211.21
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Peter A, et al. Methods of treating autoimmune disease. WO2017165508A1. WIPO (PCT) . 2017-03-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
MHC II
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