FMP-API-1

FMP-API-1 is an A-kinase anchoring protein (AKAP) -PKA interaction inhibitor. FMP-API-1 binds to the allosteric site of PKA R subunits and increases the activity of PKA and AQP2 in PKA-knockout cell lines of renal cortical collecting ducts (mpkCCD cells) . FMP-API-1 has the potential for the study of nephrogenic diabetes insipidus (NDI) [1][2].

Product Specifications

CAS Number

[16523-28-7]

UNSPSC

12352005

Hazard Statement

H317-H319

Target

PKA

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Metabolic Disease

Smiles

C1=CC(=C(C=C1CC2=CC(=C(C=C2)O)N)N)O

Molecular Formula

C13H14N2O2

Molecular Weight

230.26

Precautions

P261-P264-P272-P280-P302+P352-P362+P364-P501

References & Citations

[1]Ando F. Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus. Clin Exp Nephrol. 2021 Oct;25 (10) :1051-1056.|[2]Fumiaki Ando, et al. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nat Commun. 2018 Apr 12;9 (1) :1411.