Tetrachlorohydroquinone

Tetrachlorohydroquinone (TCHQ) is a metabolite of Pentachlorophenol. Tetrachlorohydroquinone induces reactive oxidant stress (ROS), inhibits apoptosis and induces necrosis in primary mouse splenocytes. Tetrachlorohydroquinone increases DNA lesions and induces oxidative stress in rodents[1].

Product Specifications

CAS Number

[87-87-6]

Product Name Alternative

TCHQ; Tetrachloroquinol

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Drug Metabolite; Necroptosis; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Concentration

10mM

Purity

98.45

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

C1(=C(C(=C(C(=C1Cl)O)Cl)Cl)O)Cl

Molecular Formula

C6H2Cl4O2

Molecular Weight

247.89

Precautions

H302, H315, H319

References & Citations

[1]Chen HM, et al. The pentachlorophenol metabolite tetrachlorohydroquinone induces massive ROS and prolonged p-ERK expression in splenocytes, leading to inhibition of apoptosis and necrotic cell death. PLoS One. 2014 Feb 26;9 (2) :e89483.