DS02312223

DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, thereby enhancing glucose uptake in the absence of insulin. DS02312223 is used in diabetes research[1].

Product Specifications

CAS Number

[2253733-45-6]

Product Name Alternative

D223

UNSPSC

12352005

Target

Molecular Glues

Related Pathways

PROTAC

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

CC(C)(OC(NCCOCCOC1=C(C=CC=C1)C2=C3SC=CC3=C(N=N2)NC4=C(C=C(C=C4)CC(N)=O)F)=O)C

Molecular Formula

C29H32FN5O5S

Molecular Weight

581.66

References & Citations

[1]Terayama K, et al. Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin. Science. 2025 Jul 24;389 (6758) :402-408.