SIRT-IN-6
SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with IC50 values of >50 μM. SIRT-IN-6 is promising for research of metabolic, inflammatory, oncologic and neurodegenerative disorders[1].
Product Specifications
CAS Number
[1431411-18-5]
UNSPSC
12352005
Hazard Statement
H301-H311-H331
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CC2=C(C(Cl)=NC=N2)S1)N
Molecular Formula
C7H4ClN3OS
Molecular Weight
213.64
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501
References & Citations
[1]Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56 (9) :3666-79.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3
Available Sizes
Curated Selection
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