SIRT-IN-6

SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with IC50 values of >50 μM. SIRT-IN-6 is promising for research of metabolic, inflammatory, oncologic and neurodegenerative disorders[1].

Product Specifications

CAS Number

[1431411-18-5]

UNSPSC

12352005

Hazard Statement

H301-H311-H331

Target

Sirtuin

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=CC2=C(C(Cl)=NC=N2)S1)N

Molecular Formula

C7H4ClN3OS

Molecular Weight

213.64

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

References & Citations

[1]Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56 (9) :3666-79.