IN04

IN04 is a inhibitor of leucine-rich repeat kinase 1 (LRRK1) . IN04 can completely block the binding of ATP to the human LRRK1 kinase domain, thereby inhibiting the kinase activity of LRRK1. IN04 can significantly impair the bone resorption ability of osteoclasts, with an IC50 value of 5.72 μM. IN04 can be used for the study of osteoporosis[1][2].

Product Specifications

CAS Number

[838816-57-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Others

Related Pathways

Others

Field of Research

Endocrinology

Smiles

O=C(OC)C1=CC=CC(NC(CSC2=NN=C(C3=CC(OC)=CC(OC)=C3)O2)=O)=C1

Molecular Formula

C20H19N3O6S

Molecular Weight

429.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Chen Z, et al. Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking. Med Chem. 2021;17 (10) :1140-1150.|[2]Si M, et al. A small molecular inhibitor of LRRK1 identified by homology modeling and virtual screening suppresses osteoclast function, but not osteoclast differentiation, in vitro. Aging (Albany NY) . 2019 May 21;11 (10) :3250-3261.