Win 47338

Win 47338 (compound 14) is a control compound of inhibitors of the mitotic kinase monopolar spindle MPS1 and Aurora kinases (AurA/AurB) (Ki>100 μM) [1].

Product Specifications

CAS Number

[80047-24-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Aurora Kinase

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Others

Smiles

O=C(C1=CC(C2=CC=NC=C2)=C(C)NC1=O)N

Molecular Formula

C12H11N3O2

Molecular Weight

229.23

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Fearon D, et al. Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5- (pyridin-4-yl) pyridin-2 (1H) -one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. Bioorg Med Chem. 2018 Jul 15;26 (11) :3021-3029.