Benzophenone-2
Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an endocrine disruptor targeting pregnane X receptor (PXR) and estrogen receptor α (ERα) . Benzophenone-2 regulates cytochrome P450 3A (CYP3A) expression by activating PXR. Benzophenone-2 is promising for research of UV filters[1][2].
Product Specifications
CAS Number
[131-55-5]
Product Name Alternative
2,2′,4,4′-Tetrahydroxybenzophenone
UNSPSC
12352005
Hazard Statement
H302, H317, H319
Target
Estrogen Receptor/ERR; Pregnane X Receptor (PXR)
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(O)C=C1O)C2=CC=C(O)C=C2O
Molecular Formula
C13H10O5
Molecular Weight
246.22
Precautions
H302, H317, H319
References & Citations
[1]Hu X, et al. Evaluation of polyhydroxybenzophenones as α-glucosidase inhibitors. Arch Pharm (Weinheim) . 2011 Feb;344 (2) :71-7.|[2]Casiano-Muñiz IM, et al. UV filter benzophenone-2: Effects on zebrafish (Danio rerio) cytochrome P450. Aquat Toxicol. 2024 Aug;273:106973.
Shipping Conditions
Room Temperature
Storage Conditions
RT, stored under nitrogen
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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